Landmark Research Journals of Medicine and Medical Sciences 
January 2016 Vol. 3(1), pp. 012-018
Copyright © 2016 Landmark Research Journals

Full Legnth Research Paper

 

Antigiardial and Cytotoxicity of Ethanolic Extract of Cyperus rotundus L 

Ahmed S. Kabbashi1*, Aisha Z. Almagboul 1, Waleed S. Koko2,  Mohammed O. Noor3,  Nadir M. Abuzeid4,  Mohammed I. Garbi5,  El-badri E. Osman6, Mahmoud M. Dahab7

 

1*Medicinal and Aromatic Plants and Traditional Medicine Research Institute (MAPTMRI), P.O. Box 2404, National Center for Research, Khartoum, Sudan.

2College of Science and Arts in Ar Rass, University of Qassim, K.S.A.

3Azal Pharmaceutical Industries, Khartoum Baahri, Sudan.

4Department of Clinical Microbiology, Faculty of Medical Laboratory, Omdurman Islamic University, Omdurman, Sudan.

5Department of Microbiology, Faculty of Medical Laboratory Sciences, International University of Africa. P.O. Box 2469 Khartoum, Sudan.

6Elsheikh Abdallah  Elbadri University, Berber, Sudan.

4Department of Microbiology, Faculty of Pure and Applied Sciences, International University of Africa. P.O. Box 2469 Khartoum, Sudan.

*Corresponding Author's Email: ahmedsak88@gmail.com

Accepted 12 January, 2015

ABSTRACT

The purpose of the  paper was to investigate the  in-vitro antigiardial activities (Giardia lamblia) and cytotoxicity (MTT assay) of  ethanol extract of Cyperus rotundus L (whole plant). The ethanol extract of C. rotundus were screened for their antigiardialal activities  (Giardia lamblia) and screened for their cytotoxicity using 3- (4, 5-dimethyl thiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT), obtained from C. rotundus (whole plant) ethanol extract which exhibited 100% inhibition  at a concentration 500 µg/ml after 96 h; this was compared with Metronidazole which gave 95% inhibition at concentration 312.5 µg/ml at the same time against Giardia lamblia. MTT assay verified the safety of the examined extract. In conclusion: These studies conducted for C. rotundus (whole plant) were proved to have potent activities against Giardia lamblia trophozoites in vitro. Index Terms- In vitro, antigiardial, Giardia lamblia, Metronidazole, cytotoxicity (MTT-assay), Cyperus rotundus L, (whole plant).

Keywords:  Sudan, Medical Plant, Cytotoxicity, Antigirdial.. 

 


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